Scientist/Sr. Scientist, Neuroscience
Annexon Biosciences is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, brain and eye. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue.
Desired Candidate Profile
We are seeking a Scientist/Sr Scientist with a background in neuroscience. Qualified candidates will have a deep understanding of disease mechanism and ability to translate basic research findings into novel drug targets, in-vivo proof of concept and clinical relevance using the best available technologies. Further, they should have a track record for being able to scientifically rationalize, develop and execute assays towards the goal of mechanistic understanding.
- Streamlining work towards target validation, screening assays to identify novel leads and select candidates for in-vivo testing for proof-of-concept studies.
- Initiating novel drug discovery projects and support existing targets from basic biology to clinical proof of concept studies.
- Supporting collaborative efforts with academic labs and with external CROs to drive new technologies and execute on project deliverables for programs.
- Working independently as well as collaboratively within a team, with excellent laboratory skills in biochemical, cellular, histological and/or functional assays.
- Provide strategic input into CNS research direction by interaction with the Executive and other Management teams.
- Identifying and prioritizing new molecular targets and/or phenotypic approaches for advancement into drug discovery programs with a focus on Neurological diseases.
- Identify and partner with GLP CROs and manage those relationships from start to finish.
- Work with Annexon’s various functional teams and groups to contribute to IND-enabling/Proof of Concept studies with selected CROs.
- Serve as an external face/role for the company in the areas of animal models, preclinical proof of concept, and externally at global conferences.
- Contribute to building a culture that embraces scientific excellence, integrity, urgency, partnerships with key stakeholders and continuous learning/improvements.
- Perform additional duties to support the safe and efficient operation of the laboratory, and other duties as assigned.
- Contributing to the shaping and executing of our research strategy for developing novel therapeutics for neurological diseases.
- Developing an excellent rapport with all sectors within Annexon.
- Working effectively on a cross-functional team to assess possible in-licensing candidates to strengthen our emerging portfolio in neurological diseases.
- Mentoring and supervising groups within Research.
- 4-10 years’ academic or industry experience post PhD is required.
- Experience in animal models of CNS disorders is required, especially in rodent models of neurodegenerative disease.
- Proven experience working with a variety of experimental technologies/platforms and models, developing novel experimental methods and data analysis routines.
- Demonstrated success in using biochemical, cellular, histological and/or functional assays to address biological questions and apply in drug discovery efforts.
- Excellent problem-solving skills and ability to take on new challenges, with excellent personal and scientific communication skills.
- Experience in fluid-biomarkers, basic protein characterization methods, Flow cytometry, proteomics, and/or genomic techniques would be a plus.
- Ability to analyze data rigorously, summarize and drive interpretations.
- Annexon’s Scientist/Sr. Scientist, Neuroscience will be required to be fully vaccinated against the Covid-19 virus. An applicant is considered fully vaccinated two weeks after their second dose in a 2-dose series, such as the Pfizer or Moderna vaccines, or two weeks after a single-dose vaccine, such as Johnson & Johnson’s Janssen vaccine. You will be required to show proof of vaccination status upon hire. The Company provides reasonable accommodations in accordance with applicable state, federal and local laws.
Annexon is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.