Make a career path with us

“The strength of the team is each individual member. The strength of each member is the team.” – Phil Jackson

Our Values

Icon of warrior bow
Warrior Spirit
Balances
Sound Judgement
Passion
five hands together
All for One
tree
Thrive!

Benefits

In addition to a stimulating and rewarding workplace, Annexon offers a competitive base salary and equity participation, as well as a comprehensive health benefit package, which includes medical, dental, vision, 401(k) and flexible spending plans. We are located in South San Francisco, CA with shuttle service from BART, CalTrain and the Ferry.

Open Positions

We are looking for talented individuals to join our experienced, collaborative and driven team. Those who are passionate about making a difference in the lives of patients and their families and who bring that drive and dedication to the workplace are encouraged to apply to our open positions below.

Associate Director/Director, Program & Portfolio Management

Development

Associate Director/Director, Program & Portfolio Management

Position Overview

The Associate Director/Director, Program & Portfolio Management is a proactive and effective problem solver who is intellectually curious and works exceedingly well with others. This role is responsible for managing and driving cross-functional activities required to advance a program from preclinical development through BLA submission. The winning skill set includes working effectively and efficiently with cross- functional groups including nonclinical, clinical, technical development, regulatory, manufacturing, commercial planning and finance. As a key member of the Core Team, the Associate Director/Director, Program & Portfolio Management will work closely with the GPL (Global Program Leader) to help establish and execute program strategy and activities, integrate cross-functional input, synthesize team recommendations, and ensure program advancement on time and on budget. Lastly, the Associate Director/Director, Program & Portfolio Management is expected to create and maintain consistent project documentation including project plans, timelines, trackers and communications.


Specific Responsibilities

  • In partnership with GPL and Core Team, develops and maintains integrated product development and lifecycle plans.
  • Creates and maintains project timelines that are critical tools for tracking progress against goals; closely and transparently manages the critical path of the project.
  • Proactively identifies critical milestones, interdependencies, risks and resource constraints that could impact project timelines and collaborates with teams to develop appropriate solutions.
  • Co-facilitates Core Team Meetings with GPL.
  • Responsible for Core Team documentation including meeting agendas, minutes, action item and decision trackers.
  • Ensures that all team members are fully informed and knowledgeable of project activities and status; optimizes communication within and between teams, in and outside of meetings.
  • Partners with Core Team to proactively address acute issues that arise.
  • Ensures that consistent project management tools and practices are used across team.
  • Supports continuous improvement efforts in Project Management practices at Annexon; leads department initiatives.
  • Ensures compliance with corporate policies and procedures, as well as, US healthcare laws and regulations.


Position Qualifications

  • Undergraduate degree in a scientific, medical or business discipline; postgraduate qualification (e.g., Ph.D., MBA, MS) or commensurate experience is a distinct advantage.
  • A minimum of 8 years of biopharmaceutical industry experience, with half in a Project Management function supporting highly matrixed drug development teams comprised of, but not limited to, functional area representatives from Research, CMC, Regulatory, Clinical, Marketing and Finance.
  • Solid understanding of activities critical to early and late stage drug development projects; commercial-stage a plus.
  • Proven ability to manage complex, cross-functional development projects with Go/No Go decisions.
  • Well-versed at scenario planning and capable of rapidly integrating new information into existing plans.
  • Excellent meeting planning and facilitation skills.
  • Highly proficient at both building and maintaining Gantt charts, tracking systems, spreadsheets and tools that support a systematic and scalable approach to managing projects.
  • Highly organized, excellent writing and oral communication skills, motivated and analytically rigorous.
  • Experienced at partnering with team members to determine planning assumptions that drive timelines and budgets.
  • Adept at skillfully managing complex and challenging situations.
  • Team-oriented, with excellent interpersonal skills (i.e. collaboration, conflict management and negotiation).
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Director, Accounting & Compliance

General & Administrative

Director, Accounting & Compliance

Job Description


Annexon Biosciences is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, brain and eye. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue. 

The Accounting & Compliance Director is a “hands on” position that will report directly to the VP, Controller, and support Annexon’s critical pipeline milestones, as well as the company’s growth toward becoming a multi-product commercial-stage biopharmaceutical company.  The position will be responsible for overseeing the financial close process, accounting operations, clinical trial and manufacturing accounting, and SOX responsibilities.  The Accounting & Compliance Director will partner with the accounting team, vendors and CRO’s (Contract Research Organizations), project teams and external auditors to meet accounting and finance objectives.  The ideal candidate will have operational experience in SOX 404(b) environment including oversight of internal controls associated with accounting activities. 


Specific Responsibilities

  • Month end close activities with oversight of all GL recorded transactions (including journal entries) and ensuring all GL accounts are properly reconciled on a timely basis maintaining GAAP compliance  
  • Maintenance and improvement of processes to support the Company’s accounting and reporting related to clinical trial and manufacturing expenses, including communicating with business partners (internal & external) for preparation of journal entries, reconciliations, audit support, SOX PBC schedules
  • Lead monthly meetings with external CRO’s, senior clinical and manufacturing management to provide project status updates and obtain validation of percentage and units completed
  • Ensure the accuracy and adequacy of various non-clinical liabilities, including accounts payable and accrued expenses, accrued compensation and related expenses, and other liabilities
  • Oversee outsourced payroll activities and ensure timely and accurate payroll processing and reconciliation
  • Oversight of equity related transactions including working with external stock plan administrator to records and reconcile equity activity 
  • Able to identify, optimize and automate accounting processes and drive efficient and streamlined close process
  • Support annual and quarterly audit preparation activities including SEC filings (10Q, 10K, 8-K, Proxy) and assist with disclosures as needed
  • Act as point person for external audit and outsourced tax group support
  • Participate and support the maintenance of Sarbanes-Oxley internal control certification requirements
  • Work with outsourced providers on ERP system design, implementation, and enhancement
  • Special projects as requested, particularly related to implementation of new processes and accounting policies 


Qualifications

  • Bachelor’s degree in Accounting or related field and CPA required with at least 8 years of experience with at least 3 years of experience in auditing (preferably in a Big 4 accounting firm)
  • Life Science industry experience preferred with specific experience in drug manufacturing and clinical trials
  • Strong knowledge of GAAP, SEC reporting and SOX 404 compliance
  • Ability to grow, manage and develop a diverse accounting team in a dynamic environment
  • Proficient using Microsoft Office Suite tools and ERP systems
  • Excellent organizational skills and an ability to prioritize effectively to deliver results within aggressive timelines with the ability to work independently and as part of a team
  • Comfortable in a fast-paced, small company environment with minimal direction and able to adjust workload based upon changing priorities
  • Ability to establish strong business relationships and interact cross-functionally at all levels.
  • Strong interpersonal skills including verbal and written communication are essential in this collaborative work environment
  • Advanced Excel skills required


Apply Online

Director, Total Rewards

General & Administrative

Summary

Annexon Biosciences is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue.

 

Responsibilities

  •  Works with the VP of HR to develop and direct the organization's compensation and benefit programs including compensation philosophy.
  • Prepares and studies salary analyses to determine employee compensation.
  • Evaluates predicted market trends and recommends revisions to company compensation and benefits plans.
  • Drives all HRIS initiatives and is responsible for implementation and management of all systems
  • Works on complex issues where analysis of situations or data requires an in-depth knowledge of the company. Participates in corporate development of methods, techniques and evaluation criteria for projects, programs, and people. Ensures budgets and schedules meet corporate requirements.
  • Design and develops salary range structures, career ladders and competencies. Ensure processes and systems that support base pay programs are competitive and support company’s compensation philosophy. 
  • Manage the administration and record keeping of health plans and leave policies.
  • Manage Employee Recognition Programs.
  • Manage compensation initiatives, such as annual focal planning, bonus plan, or FLSA audit, by developing in-depth project plans and leading the design, implementation and communication efforts. 
  • Periodically conduct analysis and review of various compensation programs and propose improvements to VP, HR. 
  • Perform ad hoc analysis and planning to continuously improve our compensation programs and processes.
  • Work with HR and Finance to maintain, develop, coordinate and implement HR-related computer systems. Maintain the accuracy and integrity of HR systems and serve as the technical point of contact for HR systems-related questions. 


Requirements

Desired Skills & Experience:

  • Demonstrated compensation background in the following areas: base salary, variable pay and performance management, equity programs, job evaluation, data analysis, retention, research and cost modeling. 
  • Proven track record in managing one or more compensation systems, including requirements definition, implementation, vendor management and system enhancements. 
  • A self-reliant achiever with ability to work independently to set and adjust priorities. 
  • Team player who can easily handle shifting priorities and multi-tasking in a deadline-oriented environment. 
  • Excellent analytical, technical, problem solving, written and oral communication skills. 
  • Detail oriented, well organized with strong time management skills. 

  Required Education

  • Bachelor’s degree in Human Resources or equivalent preferred.

 Required Experience

  • 7+ years of benefits and compensation experience.
  • Experience with HRIS system implementation.
  • Knowledge of federal and state regulatory requirement for compensation, benefits, HRIS and HR documentation.
  • Strong quantitative and analytical skills.
  • Strong project management experience and effective organizational skills.
  • Advanced proficiency in Microsoft Excel, Word, PowerPoint and database reporting. 
Apply Online

Head of Clinical Biomarkers (SSF, CA or Remote)

Development

Head of Clinical Biomarkers 

The Head of Clinical Biomarkers is responsible for developing and implementing strategies for clinical biomarkers across the entire Annexon discovery and development portfolio. This strategy is critical to Annexon’s precision medicine approach in the key therapeutic areas of Autoimmune diseases, Neuroscience and Ophthalmology. This individual will serve as an important Annexon leader and integrator between research and development. He/she will also oversee operational aspects such as the collection and analysis of all clinical biosamples and interfacing with external vendors to obtain timely and high-quality data.

Responsibilities

• Develop biomarker strategies to enable precision medicine approaches and optimal selection of patient indication and patient subsets in clinical trials.

• Develop biomarker strategy to align the clinical development plan from Phase I to III.

• Supervise biomarker assay development, validation and implementation.

• Lead operations for collection, management and analysis of clinical trial patient biomarker samples.

• Develop biomarker analysis plan and oversee biomarker data analysis; leads the analysis of biomarkers for clinical studies by working with key internal stakeholders and external CROs as needed.

• Provide consultation to pre-clinical programs to drive formulation of biomarker strategy at an early stage of development.

• Responsible for the integration of scientific learnings and clinical biomarker data to define targeted patient populations and enable selection of potential diagnostic platforms.

• Provides expert guidance to multi-disciplinary teams and senior management; act as the Biomarker representative on Project teams.

• Author biomarker strategy documents, biomarker specific portion of clinical protocols, and regulatory documents.

• Use biomarkers to identify opportunities to study compounds in new indications/combinations. • Identify, establish and oversee external collaborations with key opinion leaders, academic sites, and CROs to advance our understanding of disease pathways and prognostic/predictive biomarkers.

Key Qualifications:

• PhD and/or post-doc training in the area of immunology, or other related medical science field with a minimum of 15 years of relevant biotechnology or pharmaceutical industry experience.

• Knowledge of biomarker discovery and development, assay development/validation, clinical discovery of biomarkers, and MoA/translational research.

• Candidate must be detail-oriented with excellent record keeping and organizational skills.

• Must be a highly flexible, results oriented, independent self-starter who enjoys working in a fast-paced and dynamic, team-oriented environment.

• Excellent collaboration, communication, and interpersonal skills are required to engage and be productive within a high achieving team environment.

• Ability to integrate complex scientific ideas, generate testable hypotheses, and execute broad understanding of drug discovery and development in both early and late stage development.

• Familiarity with regulatory approval process.

• Basic understanding of technical aspects of companion diagnostics development

• Proven scientific/leadership expertise (working in teams, managing people/projects commensurate with a senior level).

• Strong experimental background and experience in hypothesis-driven biological/translational research with demonstrated ability to execute well-designed experiments.

Apply Online

Senior Corporate Counsel

General & Administrative

Senior Corporate Counsel


Annexon Biosciences is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue.

Annexon is looking for an energetic and talented individual to join its lean legal team. Reporting to the VP, Legal and IP, the successful candidate will interact with all levels of the organization including executive management and be a crucial part of building out the legal infrastructure of a growing company, with an initial focus on the contracts function. The candidate will be expected to take the knowledge they have amassed at a national law firm and/ or in-house life sciences experience and apply it appropriately to a growth-stage company. The successful candidate will have significant experience handling the variety of contracts necessary for the startup and conduct of global clinical trials, and a willingness to expand into other substantive areas to support business needs.


Responsibilities

Clinical and Manufacturing Contracts

  • Draft and negotiate high-volume of specialized agreements necessary for the startup and conduct of clinical trials, including confidentiality, vendor/CRO services, clinical trial, investigator-initiated studies, informed consents and letters of indemnity. 
  • Ensure the consistent and timely delivery of high quality and compliant agreements while providing clear, practical and business-oriented guidance on all contracting issues through the entire contracting process.
  • Establish strong, collaborative relationships with clinical department colleagues to support the training and education of internal clients on company policies and good contracting practices.
  • Advise internal clients on contract interpretation, dispute resolutions and legal and business risk.
  • May provide legal support for non-clinical contracting needs.

Contracts Management

  • Works with the VP, Legal and IP to develop and implement new contracts policies and procedures.
  • Contributes to the establishment and ongoing improvement of contracting parameters and procedures, including template development across various jurisdictions worldwide and associated playbooks.
  • Assist with ensuring contractual documents are processed and appropriately maintained in the company's contracts management system.
  • Train and guide business teams on the use of contract templates, relevant legal issues, processes, and good contracting practices.


Qualifications

  • J.D. degree from an ABA accredited law school; admission in good standing with any state bar (California preferred).
  • At least 5 years of experience drafting and negotiating contracts, with a focus on clinical contracts, in the life sciences industry.
  • Prior in-house experience as a member of a legal department in a biotechnology or pharmaceutical company is strongly preferred.
  • Excellent written and verbal communication skills, attention to detail, good business judgement and the ability to work independently and as a member of a team, while meeting aggressive deadlines and juggling multiple matters at one time.
  • Enthusiastic and resourceful.
  • Process oriented with attention to detail and strong analytical thinking skills.
  • Excellent communication skills, both verbal and written.
  • Experience with biotech/pharma industry required.


Apply Online

Sr. Director, Global Clinical Operations

Development

Senior Director, Global Clinical Operations

Job Description 

Annexon Biosciences is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue.

This position reports into the Vice President of Global Clinical Operations. The Sr. Director will contribute to the development and implementation of clinical studies. Responsibilities include providing leadership to staff and study teams to ensure clinical trials are conducted in accordance with the protocols, Standard Operations Procedures (SOPs), Good Clinical Practices (GCPs), and other applicable regulatory requirements. Establish and lead meetings with CROs and other trial vendors and serve as a key escalation point for teams and vendors. The Sr. Director will contribute Clinical Operations expertise in cross-functional meetings and develop and implement department initiatives. Management and mentoring of direct reports (Director through entry level) is expected.

Responsibilities

  • Accountable for the oversight and execution of multiple clinical trials including:
  • Member of core team(s) providing strategic direction to study teams to meet corporate goals and timelines
  • Develop, implement, and provide oversight of vendor budgets and contracts
  • Tracking and reporting of study metrics
  • Identify and mitigate risks to study implementation, enrollment, conduct, compliance, and completion
  • Develop and manage effective working relationships with Investigators and other key clinical opinion leaders
  • Provides technical expertise for the development of clinical documents (protocols, monitoring plans, clinical trials report, investigator brochures, etc.) and trial conduct
  • Remains current with therapeutic areas under study, industry practices / trends and FDA requirements. Applies this knowledge to current programs.
  • Partners with and maintains regular contact with key stakeholders including Regulatory, Clinical Development, Legal, Finance, and others as necessary
  • Leads the team in the selection of Contract Research Organizations (CROs) for both large budget and small budget
  • Attends CRO or other vendor meetings such as project kick-off and investigator meetings, quarterly face-to-face meetings, and others as necessary to assure alignment and achievement of study goals
  • Contributes to definition, development, and implementation of Clinical Operations functional initiatives for role clarity and institution of best practices
  • Travel may be required up to 30% in support of clinical study activities

Qualifications

  • BS/BA or MS/MA degree in related discipline or equivalent combination of education and experience
  • A minimum of 10 years of experience leading clinical trial operations including multinational/multisite clinical studies with experience in neurology and/or ophthalmology drug development. 
  • Strong leadership skills with ability to be hands-on and lead/ manage the clinical team
  • Experience with direct line-management of clinical operations staff
  • Has a thorough knowledge of the clinical development process, FDA, EMA and other regulatory requirements that may impact global clinical studies as well as ICH and GCP guidelines 
  • Has demonstrated success identifying, negotiating and overseeing outsourced clinical operations services and vendors 
  • Experience with financial budgeting or reporting 
  • Ability to interact with investigators, vendors, and individuals at all levels of the organization 


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SVP, Global Development Operations

Development


Sr. Vice President, Global Development Operations

Annexon Biosciences is a clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue.

The Sr. Vice President, Global Development Operations will be responsible for leading and integrating key operational functions within Development and will participate in the development and implementation of clinical strategies in collaboration with other functional leaders in Clinical Development, Clinical Operations, Portfolio Strategy & Operations, Data Management, Biostatistics, Regulatory Affairs, Pharmacovigilance, Research, Finance, Legal and HR. This position reports into the Chief Medical Officer.


Primary Responsibilities

  • Lead and integrate Clinical Operations, Data Management and Pharmacovigilance functions across Annexon’s Development portfolio with accountability for allocating resources, development, mentoring, management and training of a high performing team.
  • Act as primary Development Operations interface with functional heads across Development and the rest of the organization to optimize planning efforts and communication.
  • Based on deep experience, provide strategic and operational leadership on the direction, planning, execution and interpretation of clinical trials at all stages.
  • Build a powerful capability for planning and modeling clinical trial timelines, enrollment assumptions, costs and generating feasibility data; Establish best practices for defining, tracking and responding in real time to clinical trial metrics for optimized operational performance and efficiency.
  • Develop a strategic and consistent approach for the selection and management of clinical study sites and external vendors (CROs) that support the clinical programs.  
  • Oversee all data management activities including case report form design, data tracking and generation; successfully manage multiple data read-outs for open label and blinded studies. 
  • Partner with leadership of internal functions including Research and Translational Medicine to ensure optimization of clinical trial biomarker sample management and operations to meet key and frequent data deliverables across portfolio.
  • Lead and provide overall guidance on pharmacovigilance activities to ensure effective operations, risk management, and clinical trial safety surveillance, including review and oversight of all safety reporting, inclusive of clinical safety signal detection and assessment. 
  • Collaborate with Regulatory Affairs to support regulatory strategy and delivery of written content and data for submissions; Ensure alignment of data output activities in collaboration with the Medical Writing department to enable the timely and high-quality completion of Clinical Study Reports, Investigator’s Brochures, Integrated Summaries, etc. 
  • Collaborate with HR and Finance teams to assess, plan and manage human and financial resources consistent with the corporate operating plan and ensure support.
  • Partner closely with Legal team to ensure that vendor and clinical site contract review processes and workflow are optimally managed.
  • Ensure that appropriate capabilities, infrastructure, systems, standards and processes are in place to support execution of Development activities.


Requirements

  • At least 20 years of related experience with 10 years in leadership roles in the biopharmaceutical industry.
  • Minimum of a B.S./B.A. degree in a relevant scientific discipline; advanced degree (PhD or MD) or commensurate industry experience.  
  • Extensive experience as a hiring manager with a proven track record for attracting talent, building and maintaining strong teams.
  • Experience managing early- and late-phase clinical studies is required; proven track record of execution and oversight of successful clinical studies (delivered on time, within budget, and with high quality).
  • Extensive expertise in developing operational strategies and strong knowledge of ICH/GCP guidelines and multinational clinical trial guidelines (including operational, regulatory, quality and legal aspects).
  • Strong therapeutic area knowledge and the ability to support the design and execution of clinical programs, preferably in the autoimmune, neurodegenerative and/or ophthalmic disease areas.
  • Experience leading and overseeing clinical trial-related pharmacovigilance activities to ensure compliance with all globally applicable laws and regulations as appropriate and local and foreign regulatory reporting requirements. 
  • Extensive familiarity with all aspects of clinical Data Management requirements, including a working knowledge of related Biostatistics and Programming principles.
  • Experience managing relationships with external medical and scientific organizations.
  • Proven ability to work and lead effectively in a highly collaborative team environment with an emphasis on problem-solving. 
  • Strong relationship management and leadership skills; strong ability to collaborate with the executive and management teams.  
  • Proven track record of experience working with contract resource organizations, functional service providers and third-party vendors; strong contract negotiation abilities and thorough understanding of all financial aspects of contracts.
  • Highly effective communicator with excellent writing and presentation skills. 




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VP, Medical Affairs

Development

Reporting into the Chief Medical Officer, the Vice President, Medical Affairs will be a core member of the clinical and medical team and will establish and lead the Medical Affairs function at Annexon Biosciences. The Vice President, Medical Affairs will be responsible for driving Annexon’s growth by providing strategic and operational leadership both cross-functionally and to a team that they will build from the ground up. This role will ultimately be responsible for ensuring launch readiness for multiple assets across multiple therapeutic areas.


Responsibilities:

  • Establish and lead the Medical Affairs function at Annexon Biosciences.
  • Oversee medical communications, medical education, congresses/conferences, KOL outreach and advisory boards; convey role of Annexon’s lead compounds in treating autoimmune and neurodegenerative diseases.
  • Work closely with cross-functional partners to understand current medical practice in the diseases of interest and what is needed to address the unmet needs from the clinical and health economics perspective. 
  • Develop and implement key medical affairs strategies and activities to support the late stage development of Annexon’s lead assets.
  • Represent company externally, oversee medical affairs aspects of development and pre-launch needs. 
  • In collaboration with the Senior leadership develop medical affairs vision, mission and department plan in alignment with related functions that will interface with the department.
  • Provide external facing leadership with KOLs. 
  • Contribute to company success through both internal and external medical education and medical/scientific information exchange and support.
  • Build relationships with key opinion leaders by providing disease state education and communicating the clinical value of Annexon’s scientific platform.


Qualifications:

  • MD with 15+ years’ experience, including at least five years of previous biopharmaceutical industry experience 
  • Experience with prelaunch and diseases in autoimmune and neurodegeneration desired
  • Ability to understand and effectively communicate scientific and medical information to both internal and external networks, in support of the scientific and business strategy 
  • Demonstrated leadership skills and experience building effective teams 
  • Excellent written and oral communication skills 
  • Ability to anticipate and adapt to change 
  • Strong interpersonal skills commensurate with the need to work closely with partners, KOL’s, consultants, and team members across functions 
  • Ability to communicate well with health care professionals; ability to establish strong relationships with peer groups, professional organizations, and other outside parties 
  • Ability to travel up to 20% 
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VP, Ophthalmology

Development

Reporting into the Chief Medical Officer, the Vice President, Ophthalmology Development will be responsible for driving Annexon’s growth by providing strategic and operational leadership both cross-functionally and to a team that They will build from the ground up. This role will entail the development, implementation, and oversight of a robust early development process for Ophthalmology-focused scientific initiatives within the company.

The Vice President will be a core member of the clinical and medical team and will contribute to devising the overall clinical strategy and ensure all activities occur in compliance with the appropriate regulations. They will provide support to translational medicine efforts within Ophthalmology, working closely with research and preclinical development to define strategy and transition compounds from research into development candidates, and ensure their effective, timely de-risking while ensuring time- and cost-efficiency of the clinical development plan and clinical trial design.


Responsibilities

  • Lead the design and execution of clinical trials for ophthalmology focused diseases in collaboration with cross-functional partners
  • Collaborate across all levels in the organization, including effective cross-functional interactions with R&D, program leadership, etc.
  • Formulate clinical development plans (CDP) that integrate scientific rationale, clinical need, clinical measurement approaches, statistical rigor, regulatory and payor requirements, and company strategy
  • Develop and implement high quality clinical studies to support the CDP including biomarker and translational studies
  • Provide medical monitoring, safety assessment, and overall oversight for all clinical trials within Ophthalmology
  • Serve as a content expert in the review of abstracts, publications, medical information letters, and other medical documents as needed
  • Provide medical input into regulatory document preparation
  • Lead content development for advisory board meetings
  • Contribute to company success through both internal and external medical education and medical/scientific information exchange and support
  • Build relationships with key external stakeholders including, but not limited to healthcare professionals at key institutions, patient advocacy groups, and regulators by providing disease state education and communicating the clinical value of Annexon’s scientific platform
  • Drive a high-performance culture by fostering innovation, personal accountability, and commitment for results


Qualifications

  • Ophthalmologist MD with 15+ years’ experience, including at least five years of previous biopharmaceutical industry experience 
  • Expertise and awareness of the landscape in early stage development in the Ophthalmology space 
  • Proven expertise in translational medicine and biomarker development 
  • Experience executing and analyzing proof-of-concept studies to drive programs forward strongly preferred 
  • Understanding of adverse events and safety packages preferred 
  • Ability to understand and effectively communicate scientific and medical information to both internal and external networks, in support of the scientific and business strategy 
  • Demonstrated leadership skills and experience building effective teams 
  • Excellent written and oral communication skills 
  • Ability to anticipate and adapt to change 
  • Strong interpersonal skills commensurate with the need to work closely with partners, investigators, contractors, consultants, and team members across functions 
  • Ability to communicate well with health care professionals; ability to establish strong relationships with peer groups, professional organizations, and other outside parties 
  • Ability to travel up to 20% 


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Annexon is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.