Make a career path with us

“The strength of the team is each individual member. The strength of each member is the team.” – Phil Jackson

Our Values

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Warrior Spirit
Balances
Sound Judgement
Passion
five hands together
All for One
tree
Thrive!

Benefits

In addition to a stimulating and rewarding workplace, Annexon offers a competitive base salary and equity participation, as well as a comprehensive health benefit package, which includes medical, dental, vision, 401(k) and flexible spending plans. We are located in South San Francisco, CA with shuttle service from BART, CalTrain and the Ferry.

Open Positions

We are looking for talented individuals to join our experienced, collaborative and driven team. Those who are passionate about making a difference in the lives of patients and their families and who bring that drive and dedication to the workplace are encouraged to apply to our open positions below.

Clinical Trial Specialist

Development

Clinical Trial Specialist

Company Summary

Annexon Biosciences is a private, clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue. 

Position Summary:

The Clinical Trial Specialist (CTS) is primarily responsible for the coordination of activities associated with the setup and management of clinical studies under the direction of, or as delegated by a member of the Global Clinical Operations team. Responsibilities will range from clinical study coordination to data entry projects and general office work.

This position will report to the Sr. Director of Clinical Operations.

Major Duties and Responsibilities:

  • Responsibilities will include, but are not limited to, the following:
  • Help provide accurate and up-to-date study status information to the organization.
  • Implement accurate tracking systems, forms, and other relevant documents to support clinical studies
  • Assist the clinical operations team with vendor management, including tracking all study invoices and payments
  • Assist in the preparation of spreadsheets, presentations, etc. utilizing Microsoft Office Suite.
  • Assist in the periodic review and QC of eTMFs to support inspection readiness and archiving of completed studies
  • Maintain electronic files of clinical trial documents for ongoing projects
  • Coordinate logistics for clinical operations team meetings, kick-off meetings, etc. Prepare draft minutes from the various meetings for review and finalization
  • Assist in the tracking of clinical lab samples for multiple clinical trials, including tracking shipments of samples from lab vendors and helping maintain documentation of reconciliation practices and follow up any outstanding items

Skills/Knowledge Required:

  • Science or nursing degree, BA, BS, RN, or higher
  • Two or more years of experience as a clinical trial assistant or clinical study coordinator
  • Knowledge of ICH GCPs is a plus
  • Proficient with MS Word, Excel, and PowerPoint
  • Strong interpersonal, communication (written and verbal)
  • Excellent organizational skills
  • Ability to work as part of a multi-functional study team
  • Based in the San Francisco Bay Area


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Head of Biostatistics

Development


Head of Biostatistics 

Company Summary 

Annexon Biosciences is a private, clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue. 

Position Summary:

Department Head responsible for overseeing the global design and development of the biostatistics function, translating the development strategies into tactical plans to support product development objectives. This individual will lead the Biostatistics function across all therapeutic areas of Annexon. The individual will be responsible for providing statistical input to development strategies, and the formulation of effective implementation plans to support product development objectives. Provide expertise and guidance in collaboration with cross-functional groups broadly across the organization in establishing strategy, study design and analyses, and will institute best practices for planning, execution, and interpretation of clinical projects and studies. Build a team and manage both internal and external resources. 

Major Duties and Responsibilities:

Responsibilities will include, but are not limited to, the following: 

• Leads, initiates, and oversees the statistical support for the development of multiple compounds within a therapeutic area in close collaboration with Clinical Development, Regulatory Affairs, Clinical Pharmacology. 

• Provides guidance and management to statisticians to ensure high quality and timely deliverables. 

• Manages resources, sets priorities, and ensures consistency and adherence to standards therein. 

• Contributes to Clinical Development Plans, submissions, and post-submission strategies, preparations and defenses. 

• Contributes to creation/maintenance of and provides training on statistical topics and departmental SOPs. 

• Resolves technical, quality, and timeline issues. 

• Identifies external statistical experts for consultation. 

• Participates in identifying strategies to optimize clinical trial design and in response to regulatory agencies' requests. 

• Represents the company in interfaces with regulatory agencies globally. 

• Serves as the statistical representative in the defense of the company position/approach on statistical issues and drug approvals. 

• Interacts and manages KOLs/CROs and represents the company in external scientific forums. 

• Represents Biostatistics function at project meetings. 

• Act as a resource/mentor to study team members. 

• Informs the long-term Biostatistics strategy and structure. 


Skills/Knowledge Required: 

• Ph.D. in statistics or related field. 

• Experience in clinical drug development, 10+ years for Ph.D. 

• Demonstrated skill in the planning, analysis and reporting of clinical trials. 

• Detailed knowledge of statistical methodologies and statistical regulatory requirements. 

• Previous direct supervisory experience of statisticians. 

• Demonstrated ability to plan, organize, and prioritize multiple work assignments, and strong project management skills. 

• In-depth knowledge of all phases of the drug development process. 

• Demonstrated ability to work in a team environment. 

• Good interpersonal, communication, writing and organizational skills. 

• Demonstrated skill in resource management, both internal and external resources. 

• Ability to research new statistical methods and ensure alignment with regulatory agencies and industry standards. 

• Abreast of clinical trial development and regulatory requirements for relevant therapeutic areas. 


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Research Associate/Sr. Research Associate

Research

Research Associate / Senior Research Associate

Job Description

Company Summary

Annexon Biosciences is a private, clinical-stage biopharmaceutical company developing a pipeline of novel therapies for patients with classical complement-mediated disorders of the body, eye and brain. The Company’s pipeline is based on its platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q, the initiating molecule of the classical complement pathway. The Company’s first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous administration in autoimmune and neurodegenerative disorders. The Company’s second product candidate, ANX007, is a monoclonal antibody antigen-binding fragment (Fab) formulated for intravitreal administration for the treatment of neurodegenerative ophthalmic disorders. Based on learnings from its initial trials, Annexon is advancing its current programs while evaluating additional orphan and large market indications. Annexon is deploying a disciplined, biomarker-driven development strategy designed to establish that each of its product candidates is engaging the specific target at a well-tolerated therapeutic dose in the intended patient tissue. 

Position Summary:

We are seeking an independent research associate / senior research associate with excellent laboratory skills and experience in neurobiology/immunology to join our multi-functional research team. This position will provide opportunities to grow and develop scientifically in complement biology and neurodegenerative disease areas via internal and collaborative efforts.  Some responsibility for general lab management is expected.  

Requirements:

  • Bachelor’s/Master’s degree in life science or related field with 3+ years of experience in research laboratory setting.
  • Hands-on expertise in ELISA-based assays and/or driving histology processing of tissue samples and analysis. Must be able to independently drive one or both techniques.
    • Independently drive histology workflow in the lab including tissue processing, sectioning, mounting, immunostaining and imaging of tissue slides.  Hands on experience with image acquisition and image analysis a plus.
    • Extensive experience with ELISA based assays, developing, troubleshooting and validation for biochemical analysis in biofluids and tissue extracts. 
  • Familiarity with a general lab techniques – SDS-PAGE, Western Blotting, and microscopy.
  • Experience with cell culture (primary and cell lines) and flow cytometry is desirable, but not required.
  • Must be able to analyze, present and discuss data in team meetings.
  • Must have strong work ethic, ability to multi-task and enjoys laboratory work.
  • Work independently and as part of a multidisciplinary team to get things done.
  • Self-motivated to look for ways to improve and promote quality.
  • Ability to interface with external CROs in driving projects, new technologies and target deliverables for our programs.


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Scientist / Sr Scientist

Research

Job Description

We are seeking an accomplished scientist in Neuroscience with a deep understanding of disease mechanism and ability to translate basic research findings into novel drug targets, in-vivo proof of concept and clinical relevance using the best available technologies.  The right person for this role will have experience in a field of neuroscience demonstrating mechanistic understanding of a biological or disease process and should have a track record for being able to scientifically rationalize, develop and execute assays towards the goal of mechanistic understanding.

Responsibilities

  • The successful candidate will have experience streamlining their work towards target validation, screening assays to identify novel leads and select candidates for in-vivo testing for proof of concept studies.
  • Initiate novel drug discovery projects and support existing targets from basic biology to clinical proof of concept studies.
  • Collaborate efforts with academic labs and with external CROs to drive new technologies and execute on project deliverables for Annexon programs.  
  • Must be independent with the ability to work collaboratively in a team, with excellent laboratory skills in biochemical, cellular, histological and/or functional assays. 

Qualifications

  • 4-10 years’ academic or industry experience post PhD in in vitro or in vivo biochemical, cellular, histological or functional biology.  
  • Proven experience working with a variety of experimental technologies/platforms and models, developing novel experimental methods and data analysis routines.  
  • Excellent problem solving skills and ability to take on new challenges, with excellent personal and scientific communication skills. 
  • Experience in fluid-biomarkers, basic protein characterization methods, Flow cytometry, proteomics, and/or genomic techniques would be a plus.
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Sr. Director, Clinical Operations

Development

Senior Director, Global Clinical Operations

Job Description 

This position reports into the Vice President of Global Clinical Operations. The Sr. Director will contribute to the development and implementation of clinical studies. Responsibilities include providing leadership to staff and study teams to ensure clinical trials are conducted in accordance with the protocols, Standard Operations Procedures (SOPs), Good Clinical Practices (GCPs), and other applicable regulatory requirements. Establish and lead meetings with CROs and other trial vendors and serve as a key escalation point for teams and vendors. The Sr. Director will contribute Clinical Operations expertise in cross-functional meetings and develop and implement department initiatives. Management and mentoring of direct reports (Director through entry level) is expected.


Responsibilities

Accountable for the oversight and execution of multiple clinical trials including:

  • Member of core team(s) providing strategic direction to study teams to meet corporate goals and timelines
  • Develop, implement, and provide oversight of vendor budgets and contracts
  • Tracking and reporting of study metrics
  • Identify and mitigate risks to study implementation, enrollment, conduct, compliance, and completion
  • Develop and manage effective working relationships with Investigators and other key clinical opinion leaders
  • Provides technical expertise for the development of clinical documents (protocols, monitoring plans, clinical trials report, investigator brochures, etc.) and trial conduct
  • Remains current with therapeutic areas under study, industry practices / trends and FDA requirements. Applies this knowledge to current programs
  • Partners with and maintains regular contact with key stakeholders including Regulatory, Clinical Development, Legal, Finance, and others as necessary
  • Leads the team in the selection of Contract Research Organizations (CROs) for both large budget and small budget
  • Attends CRO or other vendor meetings such as project kick-off and investigator meetings, quarterly face-to-face meetings, and others as necessary to assure alignment and achievement of study goals
  • Contributes to definition, development, and implementation of Clinical Operations functional initiatives for role clarity and institution of best practices
  • Travel may be required up to 30% in support of clinical study activities


Key Qualifications:

  • BS/BA or MS/MA degree in related discipline or equivalent combination of education and experience
  • A minimum of 15 years of experience leading clinical trial operations including multinational/multisite clinical studies with experience in neurology and ophthalmology drug development. Strong leadership skills with ability to be hands-on and lead/ manage the clinical team.  Experience with direct line-management of clinical operations staff.
  • Has a thorough knowledge of the clinical development process, FDA, EMA and other regulatory requirements that may impact global clinical studies as well as ICH and GCP guidelines 
  • Has demonstrated success identifying, negotiating and overseeing outsourced clinical operations services and vendors 
  • Experience with financial budgeting or reporting 
  • Ability to interact with investigators, vendors, and individuals at all levels of the organization 


Apply Online

Annexon is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.