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Job Description

Company Summary

Annexon Biosciences is a clinical-stage biopharmaceutical company developing a new class of
complement medicines for patients with classical complement-mediated autoimmune,
neurodegenerative, and ophthalmic disorders of the body, brain, and eye. The company’s pipeline is
based on its platform technology addressing a broad spectrum of well-researched classical complement mediated autoimmune and neurodegenerative diseases triggered by aberrant activation of C1q, the
initiating molecule of the classical complement pathway. Annexon is advancing a portfolio of innovative
product candidates designed to block the activity of C1q and the entire classical complement pathway:
ANX005 (intravenous administration), ANX007 (intravitreal administration), and ANX009 (subcutaneous administration). Annexon is deploying a disciplined, biomarker-driven strategy designed to improve the probability of technical success of its portfolio.

Desired Candidate Profile

Reporting directly to the Senior Vice President, Portfolio Strategy and Operations, the Head of the
Program Management Office will lead the program manager team, work with functional leaders to set
and achieve program goals and shape the Annexon pipeline. You will ensure that the program
management office coordinates, tracks and helps advance both program activities as well as activities of
internal functional areas (as needed), external collaborators and service providers to achieve program
milestones/goals and corporate objectives. You will leverage a strong scientific background, coupled
with excellent leadership and project management skills. In this role, you will consistently and effectively
communicate with senior members of management, and others, regarding program strategies,
resources, timelines, etc. You will be a key resource in proactively integrating multiple functions and
activities, as well as proactively identifying and helping to drive decision making and resolution of
program related matters and the overall Annexon portfolio as appropriate. This role will be part of the
Annexon Leadership team.

Specific Responsibilities

• Manage the PMO and provide senior level oversight of all programs
• Oversee and mentor the professional development of PMO members
• Leverage PMO resources to support both programs and functions as needed
• With SVP, PS&O, continually optimize core team structure / function
• Ensure development of product development plans, including realistic timelines, budget, risk assessment and contingency planning (partnered with SVP, PS&O)
• Facilitate development of annual operating plan and mid-year reforecasting (in partnership with finance) including
o Development of near term and long term program objectives
o Identification of key decision milestones
o Link program timelines to functional areas and budgets to ensure optimal utilization of capital and human resources
• Facilitate prioritization of resources / budgets within programs and across programs November 2021
• Ensure cross-functional alignment and organizational support for the execution of the
operational plan
• Ensure adherence to program timelines and budgets
• Communicate progress of all programs through activities including:
o Monthly program reviews
o Maintain program dashboards
• Constantly identify key hurdles across programs, with PMs, and paths to addressing these
• With SVP, PS&O, ensure appropriate governance review of program activities, including capturing and communicating key decisions

Key Qualifications

• The successful candidate should have an advanced degree in life sciences or medicine (PhD or MD) and/or commensurate experience. He/she will have at least 10 years of industry experience in drug development, including experience in early phase non-clinical and clinical drug development, regulatory knowledge and pre-commercial market preparation.
• Will have a proven track record of being a results-oriented leader and will have 5+ yrs. of people management experience
• Advanced project management experience
• Expert planning and tracking skills, able to see big picture, well-organized, focused on results,
capable of managing multiple projects, excellent time management with respect to priorities and self-management
• Excellent cross-functional team and relationship building skills
• Understands financial aspects, including knowledge of resource planning (headcount and budget) and management
• Ability to critically and objective interpret and evaluate scientific and competitive, business related information.
• Strong verbal communication. Expert in written communications
• Experience with both small molecule and biologic development preferred
• Start-up company experience, highly desirable

Annexon’s Senior Director / Vice President, PMO will be required to be fully vaccinated against the Covid-19 virus. An applicant is considered fully vaccinated two weeks after their second dose in a 2- dose series, such as the Pfizer or Moderna vaccines, or two weeks after a single-dose vaccine, such as Johnson & Johnson’s Janssen vaccine. You will be required to show proof of vaccination status upon hire. The Company provides reasonable accommodations in accordance with applicable state, federal and local laws.


Annexon is an equal opportunity employer & prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital & veteran status.