OUR PATH TO DEVELOP CLINICAL-STAGE
Our product candidates are designed to block C1q and the entire classical complement pathway in a broad set of complement-mediated diseases. Our pipeline is based on our platform technology addressing well-researched classical complement-mediated autoimmune and neurodegenerative disease processes, both of which are triggered by aberrant activation of C1q. Evidence suggests that potent and selective inhibition of C1q can prevent tissue damage in antibody-mediated autoimmune disease and protect against the loss of functioning synapses that drives cognitive and functional decline in complement-mediated neurodegeneration.
Our first product candidate, ANX005, is a full-length monoclonal antibody formulated for intravenous (IV) administration in autoimmune and neurodegenerative disorders. Our second product candidate, ANX007, is an antigen-binding fragment, or Fab, formulated for intravitreal (IVT) administration for the treatment of neurodegenerative ophthalmic disorders. We are also developing ANX009, an investigational, subcutaneous formulation designed for the treatment of systemic autoimmune diseases.
We have completed Phase 1b clinical trials for ANX005 and ANX007 in patients with Guillain-Barré Syndrome (GBS) and glaucoma, respectively. Both molecules were well-tolerated and showed full inhibition of C1q and the classical complement pathway. Additionally, we have expanded the ANX005 clinical program into complement-mediated neurodegenerative diseases of the brain. A Phase 2 trial of ANX005 in patients with Huntington’s Disease is ongoing.
We are deploying a disciplined, biomarker-driven development strategy designed to establish that our product candidates are engaging the target at a well-tolerated therapeutic dose in the intended tissue compartments. We are also developing additional product candidates designed to inhibit C1q and other components of the early classical complement cascade with the goal of further broadening our portfolio. We hold worldwide development and commercialization rights to all of our product candidates.
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